Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorAlbert Einstein College of Medicine

About this trial

The goal of this one-arm clinical trial is to determine whether participants with mild cognitive impairment (MCI) can successfully navigate a virtual reality (VR) maze. The VR maze is designed as a training tool aimed at improving participants' spatial navigation abilities.

Main Aims:

1. To determine whether at least 70% of older adults enrolled in the study can complete twenty-four 50-minute training sessions over a 4-month period. 2. To assess whether combining virtual reality with EEG recordings can be used to measure brain activation and changes in brain activation associated with spatial navigation learning.

Participants will:

1. Walk in an open, unobstructed space while wearing VR goggles. 2. Explore up to fifty different virtual mazes in sequence and attempt to find their way through each one.

Eligibility criteria

Qualifiers

Age 65 and older with amnestic mild cognitive impairment (aMCI);

Can speak English;

Agrees to MoBI recording;

Normal or corrected-to-normal vision/audition;

Disqualifiers

Dementia (Memory Impairment/AD8 screen);

Medical conditions that affect participation such as vertigo and neck pain;

Hospitalization in the past six months or plans for surgery affecting participation in the next four months;

Mobility limitations solely due to musculoskeletal limitation or pain;

Trial design

Treatments tested in this trial

  • Spatial Navigation training

Treatment groups

30 Participants
are divided into 1 treatment group

Sponsors and collaborators

Albert Einstein College of Medicine

Lead sponsor

National Institute on Aging (NIA)

Collaborator