Detection and Management of Sinusitis in a Single-center Prospective Cohort of Patients With Exudative AMD (SINE)

ConditionAMD
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorFondation Ophtalmologique Adolphe de Rothschild

About this trial

An inflammatory component associated with AMD has been highlighted by genetic associations of predisposition to AMD, as well as by the recently demonstrated link between AMD and periodontitis.

Some patients followed at the Fondation Adolphe de Rothschild Hospital for wet AMD seemed to show an improvement of neovascular activity (less need for intravitreal injections of anti-VEGF) after treatment of their sinusitis.

The investigators would therefore like to assess the link between AMD and sinusitis, an infection close to the site of AMD.

Eligibility criteria

Qualifiers

Age ≥ 18 years

Patient followed and treated for at least 2 years for bilateral neovascular form of age-related macular degeneration (AMD)

At least one eye treated with ≥ 6 intravitreal injections during the year preceding preinclusion

Express consent to participate in the study

Disqualifiers

Persons referred to in articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of liberty by judicial or administrative decision, minors, and persons under legal protection: guardianship or curatorship).

Severe myopia (> 6 diopters)

Patient already being treated for acute or chronic sinusitis

History of central serous chorioretinopathy or diffuse retinal epitheliopathy

Trial design

Treatments tested in this trial

  • sinusitis screening consultation

Treatment groups

No treatment groups listed