Determination of Epigenetic Markers of Acute Myeloblastic Leukemia in Elderly Patients

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60+
SponsorGroupe Hospitalier de la Region de Mulhouse et Sud Alsace

About this trial

The main objective of this study is to identify epigenetic markers specific to abnormal myeloid cells in patients with acute myeloid leukemia (AML) by analyzing the methylation of circulating cell-free DNA in plasma.

Eligibility criteria

Qualifiers

/ Control Group

Age ≥ 60 years;

Scheduled for cardiac surgery involving sternotomy;

Normal blood count within the two months preceding sampling;

Disqualifiers

Patients deemed unsuitable for sampling by the surgeon performing the procedure;

Patients under legal protection measures;

Patients under judicial supervision or deprived of liberty by judicial or administrative decision;

Presence of positive virological markers indicating active infection (hepatitis B, hepatitis C, or HIV).

Trial design

Treatments tested in this trial

  • Epigenetic markers

Treatment groups

30 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Groupe Hospitalier de la Region de Mulhouse et Sud Alsace

Lead sponsor

Institut de Recherche en Hématologie et Transplantation (IRHT)

Collaborator