Determining the Effects of Ischemic Conditioning and Neuromuscular Electrical Stimulation on Overall Function After Lower Limb Amputation

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Illinois at Chicago

About this trial

The goal of this clinical trial is to learn if ischemic conditioning and neuromuscular electrical stimulation improves muscle strength and walking behavior in those with limb loss. The main questions this trial aims to answer are:

Does neuromuscular electrical stimulation improve muscle strength and gait behavior in people who have a leg amputation?

Does neuromuscular electrical stimulation boost the effects of ischemic conditioning on muscle strength and gait behavior in people who have a leg amputation?

Researchers will compare the effects of neuromuscular electrical stimulation to ischemic conditioning to see if there are any significant differences between the impacts of each intervention. Also, researchers will use both interventions together to see if the interventions can boost each other's positive impacts on walking and function in people with leg amputation.

Participants will:

* Do ischemic conditioning OR neuromuscular electrical stimulation OR both interventions at home every other day for 2 weeks * Visit the laboratory before and after completing interventions for the tests * Visit the laboratory one week after the post intervention visit for follow-up tests

Eligibility criteria

Qualifiers

Older than 18 years old

History of unilateral transfemoral or transtibial amputation

Able to ambulate independently without the use of aids (i.e., walking cane)

Able to walk at least 6 minutes continuously without stopping.

Disqualifiers

Younger than 18 years old

Inability to give informed consent

Neurological disorder such as multiple sclerosis that affects gait

Currently pregnant (or intend to become pregnant while participating in study)

Trial design

Treatments tested in this trial

  • Blood pressure cuff
  • Neuromuscular Electrical Stimulation

Treatment groups

24 Participants
are divided into 3 treatment groups