Deuterium Metabolic Imaging in People with Multiple Sclerosis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-60
SponsorUniversity of Aarhus
About this trial
The goal of this case-control study is to investigate glucose brain metabolism in people with multiple sclerosis and age- and sex-matched healthy controls. The main questions it aims to answer are:
* How does brain glucose metabolism in people with multiple sclerosis compare to age- and sex-matched healthy controls? * How is the brain glucose metabolism of people with multiple sclerosis associated with disease severity?
Participants will come in for testing lasting approximately three hours and undergo deuterium metabolic imaging, physical function test, cognitive function test, and answer survey.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Aged 18-60 years.
Definite Relapsing remitting multiple sclerosis diagnosis according to the most recent diagnostic criteria
Disqualifiers
Pregnancy
Competing neurological, psychiatric, or systemic diseases including diabetes (except prior TIA, unspecific brain MRI findings, hypertension, atherosclerosis and hyperlipidemia/cholesterolemia which are allowed).
Participating in other clinical trials with investigational medical products or drugs.
Trial population
The study seeks to include people with relapsing remitting multiple sclerosis that are otherwise healthy and age- and sex-matched healthy control participants.
Trial design
Design model
Case-control
Time perspective
Cross-sectional
Treatments tested in this trial
No Interventions
Other interventionNo delivered intervention.
Treatment groups
20 Participants
are divided into 2 treatment groupsGroup A: MS group1 intervention
Group B: HC group1 intervention
Trial outcomes
Primary outcomes
1
lactate to glx ratio
Brain deuterium metabolic imaging determined lactate to glx ratio
Time frame
2 hours from enrollment to end of assessmentSecondary outcomes
1
Six-minute walk test
Measure of walking capacity as meters walking in six minutes
Time frame
3 hours from enrollment to end of assessment2
25 meter walk test
Maximal and usual walking speed over 25 feet including a 3 m measurement
Time frame
3 hours from enrollment to end of assessment3
Six-spot-step-test
Fastes time to kick six block away from six markings on the floor approximatly 1 meter from another in a zig-zag patteren.
Time frame
3 hours from enrollment to end of assessment4
Handgrip strength
Handgrip dynamometry
Time frame
3 hours from enrollment to end of assessmentSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov