Developing a Clinical Outcome Assessment for Opioid Craving

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorJohns Hopkins University

About this trial

The purpose of this study is to collect information about opioid craving so that the investigators can develop an opioid craving assessment to improve treatments for individuals with opioid use disorder. To collect this information, the investigators are recruiting individuals in treatment for opioid use disorder who will complete cue-induced opioid craving tasks where these individuals will: (1) look at pictures of neutral objects and touch neutral objects (e.g., water bottles or flashlights), (2) look at opioid-related images, and (3) look and touch opioid-related objects. Participants will then complete a one-on-one interview about the thoughts, feelings and physical sensations the participants experienced during the cue-induced craving session. Participants will also complete questionnaires and existing opioid craving assessments. Finally, participants will provide formal feedback about existing opioid craving assessments with cognitive interviews.

Eligibility criteria

Qualifiers

18 years of age and older

Opioid-positive urine sample at admission visit (excluding individuals receiving Naltrexone).

Current opioid use disorder per Diagnostic Statistical Manual (DSM)-5

Currently in treatment for opioid use disorder

Disqualifiers

Being pregnant or breastfeeding, or may become pregnant during the trial

History of psychosis or mania or other serious psychiatric disorders assessed by the Mini International Neuropsychiatric Interview

Past 30-day suicidal behavior assessed by the Columbia Suicide Severity Rating Scale

Have circumstances that would interfere with study participation (e.g., impending jail).

Trial design

Treatments tested in this trial

  • Neutral Cue-induced Craving
  • Visual Opioid Cue-induced Craving
  • Visual and Tactile Opioid Cue-induced Craving

Treatment groups

81 Participants
are divided into 1 treatment group

Sponsors and collaborators

Johns Hopkins University

Lead sponsor

National Institute on Drug Abuse (NIDA)

Collaborator