Developing Trustworthy Artificial Intelligence (AI)-Driven Tools to Predict Vascular Disease Risk and Progression

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age40-90
SponsorAmsterdam UMC, location VUmc

About this trial

The VASCULAID-RETRO study, within the broader VASCULAID project, aims to create artificial intelligence (AI) algorithms that can predict cardiovascular events and the progression of abdominal aortic aneurysm (AAA) and peripheral arterial disease (PAD). The study plans to gather and analyze data from at least 5000 AAA and 6000 PAD patients, combining existing cohorts and retrospectively collected data. During this project, AI tools will be developed to perform automatic anatomical segmentation and analyses on multimodal imaging. AI prediction algorithms will be developed based on multisource data (imaging, medical history, -omics).

Eligibility criteria

Qualifiers

Males and females, 40-90 years old, with an AAA >3cm. This includes patients with infrarenal, juxtarenal, suprarenal, iliac (defined as 1.5x its normal diameter) aneurysms, as well as mycotic aneurysms. Patients that have had interventions or ruptures will also be included

Males and females, 40-90 years old, all PAD patients (Fontaine stages 1,2,3, and 4).

Disqualifiers

Patients with an ascending, thoracic, thoracoabdominal (type 1-3) aneurysm.

Trial design

Treatments tested in this trial

  • No intervention, retrospective study

Treatment groups

11,000 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Amsterdam UMC, location VUmc

Lead sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Collaborator

Technical University of Twente

Collaborator

Universidade do Porto

Collaborator

Centre Hospitalier Universitaire de Nice

Collaborator

Stichting Allai

Collaborator

University of Belgrade

Collaborator

Brightfish Be

Collaborator

Hospital District of Helsinki and Uusimaa

Collaborator

University of Bergen

Collaborator

Asklepios Kliniken Hamburg GmbH

Collaborator

University of Oxford

Collaborator

VINČA INSTITUTE OF NUCLEAR SCIENCES Belgrado

Collaborator