About this trial
In this project, ocular motor, pupil and gait data in people with Parkinson's disease (PD) will be collected in order to develop machine learning models for the diagnosis and monitoring of PD. With this, the investigators aim to advance the state of the art in PD diagnosis and monitoring. By integrating the principles of machine learning with high-quality sensor data, more accurate and earlier diagnosis could potentially be achieved. Ocular motor and pupil data will be collected with the standard clinical examination and with neos, a medical device approved for objective ocular motor and pupil measurement. Gait will be collected using an IMU sensor and GaitQ senti, a consumer device that allows for an objective and continuous remote gait monitoring.
Eligibility criteria
Qualifiers
Diagnosis of Parkinson's disease or of another parkinsonian syndrome (atypical Parkinson's)
Refractive error between -6 and +4 diopters, on both eyes
Informed consent by participant documented per signature
Able to self-report history of daily gait freezing and/or festination
Disqualifiers
Other known neurological diseases
Current medication/drugs that could potentially influence performance in ocular motor tasks and/or compliance in the judgement of the investigator (e.g. benzodiazepines, alcohol, stimulants, or recreational drugs) - except Parkinson's medications
Incapacity to understand and comply with the examination (e.g. due to advanced cognitive decline, failure to comply with easy experimental instructions and tasks)
Any injury or disorder that may affect eye movement measurements or balance (other than Parkinson's or referring primary condition)
Trial design
Treatments tested in this trial
- oculomotor and pupillary function assessment
Treatment groups
Sponsors and collaborators
machineMD AG
Lead sponsor
University of Zurich
Collaborator
University Hospital, Zürich
Collaborator
University of Exeter
Collaborator
gaitQ Limited
Collaborator