Development of Digital Diagnostic Devices for Parkinson's Disease

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsormachineMD AG

About this trial

In this project, ocular motor, pupil and gait data in people with Parkinson's disease (PD) will be collected in order to develop machine learning models for the diagnosis and monitoring of PD. With this, the investigators aim to advance the state of the art in PD diagnosis and monitoring. By integrating the principles of machine learning with high-quality sensor data, more accurate and earlier diagnosis could potentially be achieved. Ocular motor and pupil data will be collected with the standard clinical examination and with neos, a medical device approved for objective ocular motor and pupil measurement. Gait will be collected using an IMU sensor and GaitQ senti, a consumer device that allows for an objective and continuous remote gait monitoring.

Eligibility criteria

Qualifiers

Diagnosis of Parkinson's disease or of another parkinsonian syndrome (atypical Parkinson's)

Refractive error between -6 and +4 diopters, on both eyes

Informed consent by participant documented per signature

Able to self-report history of daily gait freezing and/or festination

Disqualifiers

Other known neurological diseases

Current medication/drugs that could potentially influence performance in ocular motor tasks and/or compliance in the judgement of the investigator (e.g. benzodiazepines, alcohol, stimulants, or recreational drugs) - except Parkinson's medications

Incapacity to understand and comply with the examination (e.g. due to advanced cognitive decline, failure to comply with easy experimental instructions and tasks)

Any injury or disorder that may affect eye movement measurements or balance (other than Parkinson's or referring primary condition)

Trial design

Treatments tested in this trial

  • oculomotor and pupillary function assessment

Treatment groups

100 Participants
are divided into 2 treatment groups

Sponsors and collaborators

machineMD AG

Lead sponsor

University of Zurich

Collaborator

University Hospital, Zürich

Collaborator

University of Exeter

Collaborator

gaitQ Limited

Collaborator