This study aims to collect tumor samples from patients carrying a mutation of interest to develop a cell culture technique for "spheroids.
The goal is to use these spheroids to model responses to anticancer treatments. Various therapeutic molecules can be tested on these spheroids, enabling the evaluation of the potential of new molecules or the activity of existing ones specifically on the tumor (bearing the mutation of interest) from which the spheroid was developed.
Tumor samples will be collected as part of biopsies or surgeries conducted during routine patient care.
Age 18 years or older.
Patient for whom at least one mutation deemed of interest by the investigator has been identified.
Patient with a malignant tumor at a locally advanced or metastatic stage, for whom a tissue tumor sample (via surgery, radiology, or endoscopy) is scheduled as part of their standard care.
Tumor volume deemed sufficient by the physician to ensure an adequate amount of material for analysis by the pathologist and the transfer of a part of the tumor sample to the Laboratory of Translational Research in Oncology for the study.
Patient with multiple primary malignant tumors.
Patient with a known HIV, Hepatitis C, or Hepatitis B infection.
Clopidogrel (hydrogensulfate) or Prasugrel (hydrochloride) or Ticlopidine (hydrochloride) with no possibility of suspension for 5 days,
Low molecular weight heparin with no possibility of dose suspension before the procedure,