About this trial
This clinical trial aims to learn if a combination of Dextran 40 and Ringer's lactate solution can improve fluid resuscitation in mild and moderate acute pancreatitis (AP) and prevent complications. The main questions it aims to answer are:
Does early fluid resuscitation with Dextran 40 plus Ringer's lactate improve patient outcomes compared to Ringer's alone? Does this treatment reduce inflammation, organ failure, and the need for intensive care unit (ICU) admission? Researchers will compare Dextran 40 plus Ringer's lactate to Ringer's alone to see if the combination therapy is more effective in reducing disease severity and complications.
Participants will:
Receive either Dextran 40 plus Ringer's lactate (1:3 ratio) or Ringer's lactate alone.
Have blood tests every 24 hours to measure inflammation and organ function. Be monitored for changes in disease severity, need for ICU admission, and hospitalization duration.
This study will help determine the best fluid resuscitation strategy for treating mild and moderate acute pancreatitis.
Eligibility criteria
Qualifiers
adults (≥18 years) diagnosed with mild or moderate acute pancreatitis
must provide written informed consent for study participation.
Disqualifiers
patients who decline to provide informed consent.
patients are non-compliant with treatment and follow-up visits.
pregnant individuals.
patients requiring concomitant treatment that is contraindicated within the study protocol.
Trial design
Treatments tested in this trial
- Ringer lactate (RLS)
- Dextran+Ringer Lactat(D+RLS)