About this trial
This observational study aims to develop novel contemporary risk factor tools for detecting young onset diabetes (under 40y) in young Asians in Singapore. The investigators aim to recruit 3000 people not currently known to have diabetes, selected across age and Body Mass Index categories, and perform formal diagnostic tests for diabetes (oral glucose tolerance test and HbA1c). The participants will also undergo continuous glucose monitoring sensor, keep a food diary, and undergo body composition analysis using bioimpedance analysis, handgrip measurements for muscle strength, and sociobehavioural profiling through download of a curated list of social media interactions. The participants will also have a blood sample retrieved and stored for subsequent comparison between people with normal glucose versus abnormal glucose levels. The whole group will also have another blood sample stored for whole gene analysis.
Eligibility criteria
Qualifiers
Asian/Part Asian ethnicity living in Singapore, not known to have diabetes
Disqualifiers
Pregnancy women
Non-Asian ethnicity
On active cancer/steroid therapy
Haemoglobinopathies or haemolytic anaemia
Trial design
Treatments tested in this trial
- Oral glucose tolerance test and HbA1c
- Anthropometric measurements
- Body impedance Analysis
- Handgrip measurement
- Continuous glucose monitoring
- Food diary recording over days 2 and 3 of continuous glucose monitoring
- Survey
- Skin reaction information
- Download of social media data
- Whole genome sequencing
Treatment groups
Locations
Sponsors and collaborators
Singapore General Hospital
Lead sponsor
SingHealth Duke-NUS Academic Medical Centre
Collaborator
Duke-NUS Centre of Quantitative Medicine
Collaborator
Data Science and Artificial intelligence Laboratory, SGH
Collaborator
Translational Research and Innovation Lab, SingHealth
Collaborator