Diabetes In Asians at Risk in Youth

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age21-39
SponsorSingapore General Hospital

About this trial

This observational study aims to develop novel contemporary risk factor tools for detecting young onset diabetes (under 40y) in young Asians in Singapore. The investigators aim to recruit 3000 people not currently known to have diabetes, selected across age and Body Mass Index categories, and perform formal diagnostic tests for diabetes (oral glucose tolerance test and HbA1c). The participants will also undergo continuous glucose monitoring sensor, keep a food diary, and undergo body composition analysis using bioimpedance analysis, handgrip measurements for muscle strength, and sociobehavioural profiling through download of a curated list of social media interactions. The participants will also have a blood sample retrieved and stored for subsequent comparison between people with normal glucose versus abnormal glucose levels. The whole group will also have another blood sample stored for whole gene analysis.

Eligibility criteria

Qualifiers

Asian/Part Asian ethnicity living in Singapore, not known to have diabetes

Disqualifiers

Pregnancy women

Non-Asian ethnicity

On active cancer/steroid therapy

Haemoglobinopathies or haemolytic anaemia

Trial design

Treatments tested in this trial

  • Oral glucose tolerance test and HbA1c
  • Anthropometric measurements
  • Body impedance Analysis
  • Handgrip measurement
  • Continuous glucose monitoring
  • Food diary recording over days 2 and 3 of continuous glucose monitoring
  • Survey
  • Skin reaction information
  • Download of social media data
  • Whole genome sequencing

Treatment groups

3,000 Participants
are divided into 1 treatment group

Locations

This trial has no locations

Sponsors and collaborators

Singapore General Hospital

Lead sponsor

SingHealth Duke-NUS Academic Medical Centre

Collaborator

Duke-NUS Centre of Quantitative Medicine

Collaborator

Data Science and Artificial intelligence Laboratory, SGH

Collaborator

Translational Research and Innovation Lab, SingHealth

Collaborator