.The goal of this interventional study is to estimate the diagnostic performance of plasma biomarkers of interest (Aβ40 and Aβ42, P-Tau and NFL), enabling discrimination between patients with and without a pathophysiological AD process. The main questions it aims to answer are:
* to define a threshold value for each of the plasma, * to describe the correlations between the plasma biomarkers of interest and the other biological analyses performed as part of care, in particular triglyceridemia, cholesterolemia, glycemia and proteinemia, * to describe biomarker results in relation to comorbidities, in particular dyslipidemia and diabetes * to describe the final diagnosis and results obtained for plasma biomarkers, for patients with intermediate results according to the A/T/N classification (A-/T+ or A+/T-) Participants will be selected among patients undergoing lumbar puncture for the differential diagnosis of AD at Nancy University Hospital.
Man or woman aged 18 or over
Person affiliated to a social security scheme or beneficiary of such a scheme
Person who has received full information on the organization of the research and has signed an informed consent form
Person whose care requires a lumbar puncture to measure markers of Alzheimer's disease
Adult subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
An adult unable to give consent
Persons deprived of their liberty by judicial or administrative decision
Persons under psychiatric care under articles L. 3212-1 and L. 3213-1.
Central Hospital, Nancy, France
Lead sponsor
Thérèse Jonveaux
Collaborator
Laure Joly
Collaborator
Lucie Hopes
Collaborator
Maia Simon
Collaborator
Franck Schreiner
Collaborator