Diaphragmatic Function and Respiratory Drive in OSA and COPD
ConditionObstructive Sleep Apnea
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorNanjing Medical University
About this trial
This cross-sectional observational study aims to assess the diaphragmatic morphofunction and respiratory drive characteristics among patients with obstructive sleep apnea (OSA), chronic obstructive pulmonary disease (COPD), overlap syndrome (OS), and healthy controls. Using ultrasound imaging and surface diaphragm electromyography (EMGdi), the study will explore group differences in diaphragmatic morphology, function, and respiratory drive indicators, and evaluate their clinical significance in disease differentiation and severity assessment.
Eligibility criteria
Qualifiers
Patients aged between 18 and 80 years.
For OSA Group: Diagnosed obstructive sleep apnea with AHI ≥ 5 events/hour based on overnight polysomnography.
For COPD Group: Diagnosed chronic obstructive pulmonary disease based on GOLD guidelines.
For Overlap Group: Diagnosed both OSA (AHI ≥ 5) and COPD.
Disqualifiers
Severe cardiovascular diseases (e.g., unstable angina, heart failure NYHA III/IV).
Severe hepatic or renal insufficiency.
Neuromuscular diseases affecting respiratory muscles.
Recent upper airway or thoracic surgery (within 3 months).
Trial design
Treatments tested in this trial
- Diaphragmatic Ultrasound and EMG Assessment
Treatment groups
80 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov