Differences in Extracellular Vesicles From Adipose Tissue of Individuals With Obesity.
ConditionObesity
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorHasselt University
About this trial
Our society is characterized by a strong increase in the prevalence of obesity, which often causes the development of cardiovascular and metabolic diseases such as type 2 diabetes. The way(s) obesity is responsible for these diseases, is still insufficiently understood. This study therefore examines the content of human fat tissue storage location- and cell type-specific extracellular vesicles (EVs) in lean and obese individuals, and the possible connection with sex, insulin sensitivity, and the blood-brain barrier.
Eligibility criteria
Qualifiers
Caucasian adults with obesity that have a body mass index (BMI) of at least 35 kg/m² and are scheduled for their first bariatric surgery.
Final male/female ratio of this study is 1:1
Minimal knowledge of Dutch to read and understand the informed consent.
Disqualifiers
Smoking and/or drug abuse
Cardiovascular diseases (including but not limited to implanted aids like a pacemaker or defibrillator)
Lung and/or kidney diseases
Brain and/or nerve diseases
Trial design
Treatments tested in this trial
- Adipose tissue biopsy
- Blood sampling
- Questionnaire
- Patient phenotyping
Treatment groups
150 Participants
are divided into 2 treatment groupsSponsors and collaborators
Hasselt University
Lead sponsor
Research Foundation Flanders
Collaborator
Ziekenhuis Oost-Limburg
Collaborator
Source ClinicalTrials.gov