Different Low Flow Rates on Gas Exchange in Children During Apnea

ConditionApnea

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age1-6

SponsorYasser S Mostafa, MD

About this trial

Effect of Low flow apneic oxygenation in pediatrics on rate of accumulation of transcutaneous carbon dioxide also, had been studied, compared to high flow rates. Furthermore, a recent study in apneic anesthetized adult discussed the rate of accumulation of carbon dioxide in arterial blood during 4 min of apnea but, no study in pediatrics discussed the effect of different low flow rates on rate of carbon dioxide accumulation during a period of apnea.

Aim of the study: the authors aim to study the effect of different flow rates of low flow oxygenation during 3 min of apnea in anesthetized children on the rate of accumulation of carbon dioxide

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Children aged 1 to 6 years old weighting 10-20 kg.

American Society of Anesthesiologists (ASA) physical status I or II.

Children will be scheduled for elective surgery under general anesthesia.

Disqualifiers

Parent refusal

Patient required nasal intubation

Children with a cardio-respiratory disease like asthma or recent upper respiratory infection.

Anemia.

Trial design

Design model

Parallel

Treatments tested in this trial

nasal cannula
Device
After induction, bag-mask ventilation with 100% oxygen and flow rates of 6 L/ min will be carried out until the expired oxygen concentration will be \>90%, saturation of oxygen was 100%, and end tidal carbon dioxide was 30-40 mmHg. Once this will be reached, bag-mask ventilation will be stopped and apneic oxygenation will be initiated for 3 minutes

Treatment groups

60 Participants

are divided into 3 treatment groups

Group A: Low groupActive comparator 1 intervention

Group B: Moderate groupActive comparator 1 intervention

Group C: High groupActive comparator 1 intervention

Trial outcomes

Primary outcomes

rise of arterial pressure of carbon dioxide

mmHg

Time frame

between 60s and 180s time points of apnea

Secondary outcomes

Time to oxygen desaturation

below 95%

Time frame

5 seconds after the onset of apnea

Number of patients reached 6 minutes of apnea

Count number of patients in each group

Time frame

1 minute after end of apneic oxygenation

Pressure difference between the end-tidal carbon dioxide and the arterial carbon dioxide

mmHg

Time frame

Between the end of apnea and the preceding blood gas

Mean difference in arterial pressure of oxygen

mmHg

Time frame

at the beginning of apnea

Other outcomes

Age

Years

Time frame

1 hour preoperatively

Weight

Kilogram

Time frame

1 hour preoperatively

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Yasser S Mostafa, MD

Lead sponsor

Fayoum University Hospital

Sponsor institution

Source ClinicalTrials.gov

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