Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversität Münster
About this trial
This study investigates the question of whether there are differences in the plasma concentration of hormones of the RAAS-axis between patients undergoing on-pump cardiac surgery and those receiving off-pump surgery
Eligibility criteria
Qualifiers
adult patients undergoing on- or off-pump coronary artery bypass graft surgery
written informed consent
Disqualifiers
emergency surgery in the context of acute coronary syndrome
ACE-inhibitor or Angiotensin 1 (AT1)-receptor-blocker intake that was not paused on the day of surgery
Chronic kidney disease with estimated glomerular filtration rate (eGFR)<30ml/min/1.73m²
Severe structural lung disease (asbestosis, silicosis, severe sarcoidosis, tuberculosis, severe emphysema, chronic obstructive pulmonary disease (COPD) Gold 3-4, lung fibrosis)
Trial design
Treatments tested in this trial
- on-pump surgery
- off-pump surgery
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov