Direct Measurement of Ingestive Behaviour in Relation to Sex Differences and Gastrointestinal Hormone Levels in Patients After Metabolic and Bariatric Surgery

ConditionObesity
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Zurich

About this trial

Bariatric surgery (BS), especially procedures like Sleeve Gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), is the most effective treatment for obesity. Yet, the exact mechanisms governing its effect are somewhat elusive, with current research mainly focusing on post-operative food intake outcomes based on self-reported data, which might not fully capture the nuanced changes in eating behaviours.

To address these gaps, our study plans to employ the newly developed "drinkometer", a device capable of analysing the intricate changes in drinking behaviour following BS. This tool promises to bring a more detailed perspective to the changes in ingestive behaviours, bypassing the inaccuracies of self-reporting methods. By expanding our research to encompass diverse patient demographics and examining potential links to physiological shifts like gut hormone level alterations, the study aims to provide a more rounded understanding of the long-term impacts of BS on eating behaviours.

Eligibility criteria

Qualifiers

Age ≥ 18 year

BMI ≥ 35 kg/m2 for patients with planned RYGB or SG operation

BMI ≥ 30 kg/m2 for external controls affected by obesity but no planned RYGB or SG within the next 12 months, and

BMI ≥ 18.5 kg/m2 and ≤ 24.9 kg/m2 for controls without obesity.

Disqualifiers

history of previous bariatric operations and/ or revisional surgery (e.g., alteration of limb lengths after primary RYGB),

smoking,

established diagnosis of type 1 or 2 diabetes mellitus, and

polycystic ovary syndrome (PCOS).

Trial design

Treatments tested in this trial

  • Bariatric Surgery

Treatment groups

420 Participants
are divided into 8 treatment groups

8

Treatment groups

See each treatment group below.

Sponsors and collaborators

University of Zurich

Lead sponsor

Florida State University

Collaborator

University College Dublin

Collaborator