Whereas the available evidence mostly supports chronic sleep disruption as a risk factor for incident AF, less is known about the near-term risk of a discrete atrial fibrillation (AF) episode following a night of disrupted or poor-quality sleep. This prospective, randomized, case-crossover study aims to examine the acute effects of sleep disruption on clinically relevant cardiac ectopy pertinent to AF.
Are age 21 years or older
Have a HGNS device implanted for obstructive sleep apnea and followed up at UCSF Health
Are willing to abstain from using the upper airway stimulation device for no more than two consecutive days as instructed over the 14-day trial period
Able and willing to provide written informed consent
Currently pregnant or trying to get pregnant
Are currently taking class 1 or 3 anti-arrhythmic medications
Have a history of permanent AF or expected to have continuous AF throughout the study period
Have congenital heart disease