Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.
Referral for initial ECT index course for Treatment-Resistant Depression (TRD), unipolar major depressive disorder or bipolar depression. Historic failure of response or remission to at least two antidepressant medications of sufficient dose and duration will be used for TRD diagnostic.
Diagnoses of schizophrenia or schizoaffective disorders.
Subjects who are unable to tolerate the Dreem device for sleep recordings will be excluded from the study.
Washington University School of Medicine
Lead sponsor
National Institute of Mental Health (NIMH)
Collaborator