Distal Perfusion Timing, Early or Conservative, to Prevent Limb Ischemia During Peripheral VA-ECMO

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19+
SponsorMin-Seok Kim

About this trial

Peripheral VA-ECMO is widely used in refractory cardiogenic shock patients as a salvage therapy. In most cases, the femoral artery and vein are used for the vascular approach. Large cannulas are usually used for proper oxygenation, which may cause peripheral limb ischemia. Distal perfusion catheterization (DPC) at the ipsilateral arterial cannula site is recommended to prevent distal limb ischemia. However, there is no consensus on the proper timing of DPC and additional invasive procedures may cause complications during VA-ECMO support. In this analysis, the investigators compare the clinical outcomes of distal limb ischemia complications between the conventional DPC group (DPC at the time of limb ischemia sign) and the preemptive DPC group (DPC at the time of VA-ECMO application).

Eligibility criteria

Qualifiers

Age ≥19 years old

Refractory cardiogenic shock with peripheral VA-ECMO

Informed consent

Disqualifiers

Unwilling or unable to obtain informed consent from the participant or substitute decision-maker

Patients who are currently pregnant, postpartum period within 30 days or are breast-feeding

VA-ECMO application for causes other than cardiogenic shock

Severe coagulopathy

Trial design

Treatments tested in this trial

  • Distal perfusion catheterization

Treatment groups

400 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Min-Seok Kim

Lead sponsor

Asan Medical Center

Sponsor institution