Does tDCS Change Synaptic Density in the Brains of Patients With Schizophrenia
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCentre for Addiction and Mental Health
About this trial
This study will examine changes in synaptic density with transcranial direct current stimulation (tDCS) in the brains of patients with schizophrenia. Synaptic density levels will be measured using a novel positron emission tomography (PET) radiotracer \[18F\]SDM-8, which is currently the best-in-class method to quantify synaptic density in humans. This will be a companion study to a parent study by our group examining the effects of tDCS on treatment adherence in schizophrenia (REB #103-2018).
Eligibility criteria
Qualifiers
Male or female participants of any race or ethnicity
Inpatients or outpatients ≥18 years of age
DSM-V diagnosis of schizophrenia or schizoaffective disorder
Capable of consenting to participate in the research study
Disqualifiers
Unwilling or incapable to consent to the study based on the MacArthur Test of Competence
Unstable medical or any concomitant major medical or neurological illness, including a history of seizures
Acute suicidal or homicidal ideation
Formal thought disorder rating ≥3 on the Positive and Negative Syndrome Scale (PANSS) P2 conceptual disorganization item
Trial design
Treatments tested in this trial
- PET Scan
Treatment groups
20 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov