The purpose of this study is to learn how drinking alcohol affects how people experience stress and how that is affected by the body's chemistry. Specifically, the investigators will be studying relationships of drinking and a stress hormone called cortisol. The investigators believe that results will lead us to find more effective ways to help people stop or reduce drinking when participants are drinking at harmful levels.
Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Medically stable male or female, aged 18-55.
Able to read, write and complete a multitude of self-assessments in English
Subjects with any significant current medical conditions (neurological, cardiovascular, endocrine, thyroid, renal, liver), seizures (for LTS subjects only- seizures directly related to alcohol detoxification are not an exclusion) , delirium or hallucinations, or other unstable medical conditions, including HIV.
Current DSM-5 substance use disorder (other than AUD or tobacco use disorder)
Any metallic objects implanted in their body which would make imaging unsafe (pacemaker, etc)
Claustrophobia, or other inability to participate in an MRI
Yale University
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborator