Health Trials

Driving Pressure-guided Lung Protective Ventilation

ConditionsHypoxemiaVentilator Lung
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age14-70
SponsorYong Lin, PhD

About this trial

The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving pressure-guided lung protective ventilation can reduce postoperative oxygenation function in patients who have undergone surgical repair of acute type A aortic dissection. The primary outcomes is the incidence of postoperative hypoxemia (a partial pressure of arterial oxygen to inspiratory oxygen fraction ratio less than 300 mm Hg or a peripheral blood oxygen saturation less than 93% at any concentration of inspiratory oxygen) within 7 days after the surgery.

Eligibility criteria

Qualifiers

Able to sign Informed Consent and Release of Medical Information Forms;

Age ≥ 14 years and ≤ 70 years old;

Being confirmed the diagnosis by chest computed tomography angiography and receiving the surgical repair of acute type A aortic dissection.

Disqualifiers

Age < 14 years or > 70 years old;

Sepsis before surgery;

Chronic pulmonary disease including lung infection or asthma requiring long-term pharmacotherapy;

History of lung tumor;

Trial design

Treatments tested in this trial

  • Driving pressure-guided positive end expiratory pressure
  • Optimal oxygenation-guided positive end expiratory pressure
  • Ventilation strategy
  • Management of hypoxemia

Treatment groups

43 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Yong Lin, PhD

Lead sponsor

Fujian Medical University Union Hospital

Sponsor institution

Source ClinicalTrials.gov