dTDI During a SBT to Predict Extubation Failure in Preterm Infants
ConditionPremature
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age2-6
SponsorWang Jianhui
About this trial
Weaning from mechanical ventilation is a critical issue and the diaphragmatic disfunction has been demonstrated to play an important role in extubation failure. the aim of present investigation is to evaluate diaphragmatic excursion velocity during in patients undergoing spontaneous breathing trial through tissue Doppler analysis in both inspiration and expiration.
Eligibility criteria
Qualifiers
premature infants with gestational age <32 weeks and supported by invasive mechanical ventilation ≥48 hours
All the indications for extubation are met：cough or vomiting due to spontaneous breathing and sputum aspiration; ventilator parameters in recent 24 hours: MAP < 8cmH2O, RR < 30 times/min, FiO2 < 30%; Arterial blood gas: pH > 7.25, (PaCO2< 60mmHg, BE < 8mmol/L, oxygen saturation > 90%
a successful SBT
parents or legal guardians sign informed consent to attend this study
Disqualifiers
accidental extubation
chest CT or bronchoscopy during hospitalization indicated congenital airway dysplasia
complex congenital heart disease
congenital metabolic diseases, neuromuscular diseases
Trial design
Treatments tested in this trial
- diaphragmatic tissue Doppler imaging，dTDI
Treatment groups
100 Participants
are divided into 2 treatment groupsSponsors and collaborators
Wang Jianhui
Lead sponsor
Children's Hospital of Chongqing Medical University
Sponsor institution
Source ClinicalTrials.gov