Dumping Syndrome and Esophageal Atresia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age2-3
SponsorUniversity Hospital, Lille
About this trial
Dumping syndrome (DS) is frequent in oesophageal atresia (29%). In causing hypoglycaemia, it can be dangerous for neonates. Mechanisms of DS are actually partialy understood. This is also an affection difficult to diagnose, because it only occurs after meals and can be inconstantly present. To date, their is only symptomatic treatment for DS. This study aims to understand its pathological mechanisms so as to better treat it and avoid its consequences. Oesophageal atresia patients enrolled in this study will benefit from a continuous glycemic monitoring, a continuous cardiac monitoring, and an a gastric emptying scintigraphy at the age of 3 months
Eligibility criteria
Qualifiers
Patients operated at birth for Oesophageal atresia type C
Aged from 2 to 3 months at inclusion
Off prokinetic treatment (suspended for at least 72 hours) before monitoring
Disqualifiers
History of dumping syndrome of other cause (microgastria, fundoplication, dysautonomia..)
History of any disease that can modify glycemic regulation (hyperinsulinism, neonatal diabete)
Treatment that can modify gastric motility
Trial design
Treatments tested in this trial
- Glycemic Holter
- gastric emptying scintigraphy
- Holter ECG
Treatment groups
15 Participants
are divided into 1 treatment groupSponsors and collaborators
University Hospital, Lille
Lead sponsor
Groupement Interrégional de Recherche Clinique et d'Innovation
Collaborator
french patient association for oesophageal atresia AFAO
Collaborator
Source ClinicalTrials.gov