Bone turnover markers (BTMs) are recommended as an important tool in follow-up of osteoporosis treatment. However, there is a lack of knowledge in the reliability of BTMs during and after glucocorticoid treatment. Glucocorticoids suppresses BTMs during treatment with at least 30% and, moreover, glucocorticoids increase the risk of fractures. Patients with an inflammatory joint disease are at increased risk of osteoporosis, and disease flares are often treated with glucocorticoids, which in turn can lead to loss in reliability of the BTMs in patients who also are on osteoporosis treatment.
There is a need of more knowledge on BTM changes during and after glucocorticoid treatment for optimized patientcare, reduced risk of side effects and reduced health economic costs.
diagnosis of inflammatory rheumatic joint disease
indication of disease modifying treatment initiation with or without glucocorticoids OR
stable DMARD treatment with parenteral glucocorticoid injection
known osteoporosis or osteoporosis treatment
women during the transitory phase
oestrogen treatment
any fracture within the last year
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Treatment groupsSee each treatment group below.
Diakonhjemmet Hospital
Lead sponsor
Vestre Viken Hospital Trust
Collaborator
Hormone Laboratory, Aker University Hospital, Oslo, Norway
Collaborator