Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorThe Methodist Hospital Research Institute

About this trial

The goal of this observational study is to investigate how bacterial populations from the intestine and mouth of patients change during the hospitalization period and evaluate if some populations of specific bacteria increase or decrease the risk of acquiring an infection or becoming colonized by pathogenic bacteria. Participants will have the following samples collected during enrollment: stool samples (maximum 2x/week), blood draws (1x/week), oral swab (1x/week).

Eligibility criteria

Qualifiers

Admission to an intensive care unit or stem cell transplant unit (for allogeneic stem cell transplantation) within previous 24 hours

Disqualifiers

<18 years of age

Pregnancy

History of inflammatory bowel disease (Crohn's disease, ulcerative colitis)

Gastrointestinal derivation (colostomy, ileostomy, etc.)

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

1,000 Participants
are grouped into 2 trial groups

Sponsors and collaborators

The Methodist Hospital Research Institute

Lead sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Collaborator

M.D. Anderson Cancer Center

Collaborator

Baylor College of Medicine

Collaborator

University of Houston

Collaborator

William Marsh Rice University

Collaborator

The University of Texas Health Science Center, Houston

Collaborator