Early Cessation of Sedation and TTM in Patients With a Favourable EEG After Cardiac Arrest
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMedisch Spectrum Twente
About this trial
The objective of this study is to estimate the feasibility and safety of early weaning from ICU treatment in patients after cardiac arrest and an early (\< 12 h) favourable EEG pattern (indicating no or mild postanoxic encephalopathy).
Eligibility criteria
Qualifiers
Patients after cardiac arrest admitted to the ICU for treatment with sedation, TTM and mechanical ventilation.
Age 18 years or older.
Continuous EEG measurement started within 12 hours after cardiac arrest.
Favourable EEG pattern within 12 hours after arrest, defined as a continuous background pattern (NVN, 2019; Ruijter et al., 2019).
Disqualifiers
A known history of another medical condition with limited life expectancy (<6 months).
Any progressive brain illness, such as a brain tumour or neurodegenerative disease.
Pre-admission Glasgow Outcome Scale Extended score of 4 or lower.
Reason other than neurological condition to continue sedation and/or ventilation.
Trial design
Treatments tested in this trial
- Early cessation of sedation and TTM
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov