About this trial
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability.
In this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.
Eligibility criteria
Qualifiers
Patients diagnosed with ischemic stroke aged 18 years or older;
Ability to undergo carotid and transcranial Doppler ultrasound, as well as to mobilize within 48 hours;
Informed consent obtained from the patient or legal representative.
Disqualifiers
Pre-existing disability with a modified Rankin Scale (mRS) score ≥ 4;
Diagnosis of Transient Ischemic Attack (TIA);
Systolic blood pressure < 100 mmHg or > 220 mmHg;
Peripheral oxygen saturation < 92%;
Trial design
Treatments tested in this trial
- Doppler-guided early mobilization
Treatment groups
Sponsors and collaborators
Unidade Local de Saúde de Coimbra, EPE
Lead sponsor
Unidade Local de Saúde São João
Collaborator
Unidade Local de Saúde Santa Maria
Collaborator