Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUnidade Local de Saúde de Coimbra, EPE

About this trial

Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability.

In this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.

Eligibility criteria

Qualifiers

Patients diagnosed with ischemic stroke aged 18 years or older;

Ability to undergo carotid and transcranial Doppler ultrasound, as well as to mobilize within 48 hours;

Informed consent obtained from the patient or legal representative.

Disqualifiers

Pre-existing disability with a modified Rankin Scale (mRS) score ≥ 4;

Diagnosis of Transient Ischemic Attack (TIA);

Systolic blood pressure < 100 mmHg or > 220 mmHg;

Peripheral oxygen saturation < 92%;

Trial design

Treatments tested in this trial

  • Doppler-guided early mobilization

Treatment groups

1,300 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Unidade Local de Saúde de Coimbra, EPE

Lead sponsor

Unidade Local de Saúde São João

Collaborator

Unidade Local de Saúde Santa Maria

Collaborator