A Pilot Trial of Disposable Nitrous Oxide Canisters in Providing Pain Control During Burn Dressing Changes

Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Manitoba

About this trial

Improvements in burn care have resulted in increased survival. Despite these improved outcomes one of the leading challenges of burn care remains providing adequate analgesia during routine wound care and dressing changes. The traditional use of narcotics is challenging as the therapeutic window between analgesia and suppression of breathing becomes narrow with the intense pain and high doses of narcotics needed for dressing changes.

Eligibility criteria

Qualifiers

adult burn patients admitted to the Health Sciences Centre

total body surface area burned of 5-20%

Disqualifiers

admitted to intensive care unit

unable to participate in the measurement outcomes (sedated, cognitively impaired, unable to understand English or visually impaired)

medical condition that precludes using nitrous oxide (respiratory disease and significant cardiovascular disease 5).

pregnant

Trial design

Treatments tested in this trial

  • Nitrous Oxide Inhalant Product
  • Placebo

Treatment groups

30 Participants
are divided into 2 treatment groups

Sponsors and collaborators