Allogeneic CD19-CAR-NK Cells in Patients With Refractory Myasthenia Gravis

Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-65
SponsorGuangdong ProCapZoom Biosciences Co., Ltd.

About this trial

This study is a single-center, prospective, nonrandom, single-arm trial.

Eligibility criteria

Qualifiers

Aged 18-65 years old, including the boundary value, no gender restriction;

MGFA clinical class II-IV;

Anti-acetylcholine-receptor antibody (AChR-Ab) shows positive;

Willing to participate in the study, understand and sign the informed consent form (ICF).

Disqualifiers

Received IVMP, IVIG, or TPE within the 2 months before the current visit;

Unable to cooperate in completing the MG-ADL, or QMG, or Quantitative QMG questionnaire.

Judged by a senior clinician to have any of the following: 1)Severe or chronic urinary-tract infection; 2)History of recurrent infections; 3)Previous allergy to any human-derived biologic drug; 4)Depression, suicidal ideation, or other psychiatric disorder;

Patients with active infection, such as herpes zoster, HIV, active tuberculosis, or active hepatitis.

Trial design

Treatments tested in this trial

  • CD19-CAR-NK Cells Injection

Treatment groups

15 Participants
are divided into 1 treatment group

Locations

This trial has no locations