Analgesic Efficacy of an Opioid-free Postoperative Pain Management Strategy Versus a Conventional Opioid-based Strategy Following Video-assisted Thoracoscopic Lobectomy

Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-65
SponsorAffiliated Cancer Hospital & Institute of Guangzhou Medical University

About this trial

Investigators have designed a randomized controlled trial. Utilizing an open-label, randomized, controlled study methodology, this trial aims to explore a opioid-free, safe, and effective analgesic approach for thoracic surgery. It also seeks to provide clinical guidance for the implementation of opioid-free or reduced-opioid postoperative analgesia in other thoracic procedures, aiming to optimize postoperative pain management for patients and ultimately enhance the overall patients recovery experience.

Eligibility criteria

Qualifiers

Aged between 18 and 65 years.

Patients with lung cancer or suspected lung cancer who are undergoing lobectomy surgery via Video-assisted thoracoscopic surgery (VATS) or Robotic-assisted thoracoscopic surgery (RATS).

American anesthesiologist association (ASA) physical status classificationⅠ-Ⅲ.

Surgery is expected to last at least 2 hours, with a minimum of 2 days of postoperative hospitalization.

Disqualifiers

Patients who underwent open-heart surgery.

Patients with BMI ≥30 kg/m², or ≤18.5 kg/m².

Patients who are allergic to any of the local anesthetic drugs, such as ropivacaine, lidocaine, bupivacaine, procaine, bupivacaine, benzocaine, dacronin, etc.

Patients who are allergic to any of the general anesthesia drugs, such as those including propofol, sufentanil, remifentanil, etc.

Trial design

Treatments tested in this trial

  • Ropivacaine
  • Sufentanil

Treatment groups

140 Participants
are divided into 2 treatment groups

Locations

This trial has no locations