The goal of this study is to investigate the safety and tolerability of the topical application of SOF-SKN in healthy volunteers. The study will be divided into part 1 and part 2.
Part 1, is a single ascending dose (SAD) design, while Part 2 is a multiple ascending dose (MAD) design.
Healthy Volunteers 18 to 64 years.
Participants with Fitzpatrick skin type I to IV.
Participants must have a back surface area of at least 24 × 30 cm to accommodate two - 10 × 30 cm application areas with a 4 cm separation between them.
No Allergies.
Allergic constitution.
Within 72 hours of the start of study treatment, the use of antihistamines or use of topical drugs at the application site.
Hair removing interventions including laser treatment, shaving and waxing in the target area within 1 week before Screening.
Hypertrichosis on the back; no tattoos that cover greater than 30% of the back surface area.
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Treatment groupsSee each treatment group below.