About this trial
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.
Eligibility criteria
Qualifiers
Unilateral stroke
Stroke occurred more than 6 months prior
Paresis confined to one side
Independently ambulatory (including the use of assistive devices)
Disqualifiers
Brainstem or cerebellar stroke
Aphasia (expressive, receptive, or global)
Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function
Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations
Trial design
Treatments tested in this trial
- Explicit motor learning
- Implicit motor learning