Cognition and Motor Learning Post-stroke

Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age45-85
SponsorUniversity of Southern California

About this trial

This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.

Eligibility criteria

Qualifiers

Unilateral stroke

Stroke occurred more than 6 months prior

Paresis confined to one side

Independently ambulatory (including the use of assistive devices)

Disqualifiers

Brainstem or cerebellar stroke

Aphasia (expressive, receptive, or global)

Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function

Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations

Trial design

Treatments tested in this trial

  • Explicit motor learning
  • Implicit motor learning

Treatment groups

65 Participants
are divided into 1 treatment group