The main objective of the proposed research study is to determine in men and women with spinal cord injury/disease and neurogenic bladder whether the dose of coupled gentamicin \& Lactobacillus rhamnosus GG affects the recolonization of the bladder, and whether the rate of success differs by sex. Secondary objectives include determining whether that recolonization lasts 7, 14, or 28 days; and safety of the coupled gentamicin \& Lactobacillus instillations.
Neurologic diagnosis
≥18 years old
Neurogenic bladder for at least 6 months
No USQNB-IC A, B1, or B2 symptoms
Known genitourinary pathology beyond NLUTD (i.e. kidney stones, bladder stones, vesicoureteral reflux, etc.)
Use of prophylactic antibiotics or any antibiotics within 2 weeks of beginning instillations
Instillation of intravesical agents other than saline bladder wash
Immunodeficiency
Medstar Health Research Institute
Lead sponsor
United States Department of Defense
Collaborator
University of Pittsburgh Medical Center
Collaborator