Diffusion MRI in Heart Failure
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-85
SponsorMassachusetts General Hospital
About this trial
The development of symptomatic heart failure is frequently preceded by a pre-clinical period of structural remodeling in the heart. The remodeling process driving this transition, however, remains poorly understood. The investigators hypothesize that imaging the diffusion of water in the heart with MRI will allow its microstructure to be resolved. The investigators further hypothesize that the characterization of microstructural changes in the heart will help elucidate the pathogenesis of heart failure and the transition from a compensated to a decompensated state. Patients with recent myocardial infarcts and left ventricular hypertrophy, who are at risk for the development of heart failure, will be enrolled. The participants will undergo serial diffusion tensor MRI (DTI) imaging of the heart to characterize changes in myocardial microstructure over time.
Eligibility criteria
Qualifiers
Healthy adults with no history of hypertension, diabetes or heart disease
Patients with ST Elevation MI within last 6-10 weeks who are angina free, and have been seen by a cardiologist since discharge
Patients with episode of heart failure within last 12 months and left ventricular hypertrophy, documented by echocardiogram or MRI.
Disqualifiers
Presence of metallic foreign bodies/objects
Selected medical devices and implants
Pacemakers, implantable defibrillators, life vests
Coronary artery stent within last 6 weeks (unless the stent is a MRI-inert chromium-cobalt stent)
Trial design
Treatments tested in this trial
- Diffusion Tensor MRI (DTI)
- Gadolinium DOTA Meglumine
Treatment groups
160 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov