Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients

Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-75
SponsorNational Institute of Cardiology, Laranjeiras, Brazil

About this trial

Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.

Eligibility criteria

Qualifiers

Resistant hypertension, with a diagnosis described in the medical record, without changing medications or increasing doses in the last 30 days.

Disqualifiers

neoplasms

heart failure

use of medications with nitrate in their formula

patients undergoing renal denervation

Trial design

Treatments tested in this trial

  • Beetroot extract
  • Placebo

Treatment groups

50 Participants
are divided into 2 treatment groups