Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors
Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age60-99
SponsorUniversity of Maryland, Baltimore
About this trial
Older ICU survivors with ICU acquired weakness (ICUAW) are malnourished, sarcopenic, and functionally debilitated as a consequence of the high burden of comorbidities common in the elderly. To address the sequalae of critical illnesses, the investigators will perform a trial incorporating an intervention that combines mobility-based physical rehabilitation (MRP), high protein supplementation (HPRO), and neuromuscular electric stimulation (NMES). The investigators will then assess both clinical and functional outcomes and determine the relationship of disability with systemic inflammation.
Eligibility criteria
Qualifiers
LTACH admission within 72 hours
Age ≥ 60 years old
Prior ICU stay ≥ 2 weeks
Able to follow commands in English
Disqualifiers
Acute kidney injury with a glomerular filtration rate <15 ml/min
Diagnosis of severe organ dysfunction including end stage liver disease or cirrhosis
Diagnosis of active cancer
Severe functional impairment or physical impairment to rehabilitation
Trial design
Treatments tested in this trial
- MRP and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES)
Treatment groups
78 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov