This is a single arm, open-label, dose escalation clinical study to evaluate the safety and tolerability of autologous mesothelin (MSLN)-targeted chimeric antigen receptor (MSLN-CAR) T cells secreting PD-1 and CTLA-4 nanobodies (αPD1/CTLA-4-MSLN-CAR T cells) in patients with solid tumors.
Patients must have a histological or cytological diagnosis of advanced solid tumors, such as non-small-cell lung cancer and mesothelioma；
Patients must have failed established standard medical anti-cancer therapies；
Greater than or equal to 18 years of age and less than or equal to 70 years of age on day of signing informed consent；
Life expectancy ≥3 months；
Prior therapy with targeted therapy or cell therapy against MSLN；
Prior therapy with any gene therapy (including CAR-T cell therapy) or any T cell therapy home and abroad；
Active bacteria, viral or fungal infection, and not contained after anti-infective therapy (positive results in the blood ≤72 hours before infusion);
Patient is positive for Syphilis, Human Immunodeficiency Virus (HIV) , active Hepatitis B (HBsAg reactive) or Hepatitis C (HCV RNA (qualitative) is detected);