The primary objective: To evaluate the efficacy of intravenous infusion of universal UC-MSCs and CD83+MSCs subpopulation injection in the treatment of sepsis by using the 28-day survival rate of the subjects as the primary efficacy criterion.The secondary objectives: 1. To systematically evaluate the safety of universal UC-MSCs and CD83+MSCs subpopulation in the treatment of sepsis; 2. To provide theoretical basis and clinical research data for establishing a safe, effective and feasible clinical treatment plan for sepsis using stem cells.
Age: 0-65 years old, diagnosed with sepsis
Clinical diagnosis of sepsis (based on Sepsis 3.0 International Guidelines)
Confirmed or suspected infection
Violation of medical ethics
Significant confounding factors likely to bias study outcomes
Poor adherence to the study protocol
Concurrent participation in other clinical trials