Impact of rTMS on Abnormal Cortical fMRI in Patients With Dystonia
ConditionDystonia Disorder
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-80
SponsorNorthwell Health
By tracking resting-state fMRI scans, we aim to discover how repetitive transcranial magnetic stimulation (rTMS) changes brain connectivity in individuals with dystonia.
Male or female
18 and 80 years of age.
Patients who manifest dystonia - sustained involuntary movement of the head, neck, trunk or limbs.
The dystonia may be spontaneous or genetic, specifically DYT1 or DYT6 and then only those patients who are demonstrating dystonia. The patient/subject will have a normal neurological exam except for dystonia.
Heredodegenrative dystonia of the type DYT8,9 or 10.
Past history of head trauma, stroke, epilepsy, demyelinating disease
Hypertension in excess of 160mmHg systolic and 90mmHg diastolic
Congestive heart failure