Losartan and Emotional Processing in Young People
ConditionEmotional Processing
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age16-20
SponsorUniversity of Oxford
About this trial
This study explores the effects of single-dose losartan (50mg) versus placebo on emotional processing in young healthy volunteers.
Eligibility criteria
Qualifiers
Willing and able to provide informed consent (for 16 and 17 year olds: assent and parental/ legal guardian consent)
Non- or light-smoker (< 5 cigarettes a day)
Ability to attend appointments in Oxford with reasonable travel costs
Ability/ willingness to provide GP contact details
Disqualifiers
Past or present DSM-5 axis-I diagnosis (based on SCID results at screening), especially severe psychiatric illness or alcohol or substance dependence
First-degree family member with severe psychiatric illness
CNS-medication last 6 weeks (including as part of another study)
Current blood pressure or other heart medication (especially aliskiren or beta blockers)
Trial design
Treatments tested in this trial
- Losartan potassium
- Placebo
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Oxford
Lead sponsor
National Institute for Health Research, United Kingdom
Collaborator
Source ClinicalTrials.gov