Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes
ConditionGestational Diabetes
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexFemale
Age18-45
SponsorAnna Stanhewicz, PhD
About this trial
The purpose of this investigation is to examine the mechanisms mediating vascular dysfunction in women who have had gestational diabetes and how metformin may be a valuable treatment tool to improve microvascular function in these women before the onset of disease.
Eligibility criteria
Qualifiers
≥12 weeks and ≤5 years postpartum
history of GDM or healthy pregnancy
Disqualifiers
prediabetes or diabetes (HbA1c ≥5.7%)
current tobacco use
cardiovascular or metabolic disease
cardiovascular or metabolic medication
Trial design
Treatments tested in this trial
- Metformin Hydrochloride
- placebo
Treatment groups
30 Participants
are divided into 2 treatment groupsSponsors and collaborators
Anna Stanhewicz, PhD
Lead sponsor
University of Iowa
Sponsor institution
Source ClinicalTrials.gov