Multi-organ Imaging of Microvascular and Metabolic Function
Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorMassachusetts General Hospital
About this trial
What if heart disease starts outside the heart? This research will study how to simultaneously assess brain and body physiology, how they are jointly related to heart function, and how their response to physical and mental stress differs in patients with heart disease.
Eligibility criteria
Qualifiers
Adults aged 18 years and older
For patients with cardiovascular disease: Documented diagnosis of ischemic heart disease based on standard clinical, radiologic, and/or histopathologic criteria, as documented in the medical record; or a clinical nuclear cardiac stress PET test within 1 year.
For healthy subjects: No diagnosis of cardiometabolic disease, cancer, or other major disease within the past 5 years
Disqualifiers
Research-related radiation exposure exceeding current MGB Radiology Department guidelines (i.e., 50 mSv in the prior 12 months);
Inability to lie comfortably on the bed inside the scanner;
Body weight > 300 lbs (weight limit of the scanner table);
Pregnancy or breastfeeding;
Trial design
Treatments tested in this trial
- 18F-FDG
- Positron Emission Tomography (PET)
Treatment groups
60 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
Source ClinicalTrials.gov