Neuro-Intermuscular Coordination Enhancement (NICE) Rehabilitation Through Human-Machine Interaction in Chronic Stroke

Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age21-80
SponsorUniversity of Houston

About this trial

The objective of this study is to develop Neuro-Intermuscular Coordination Enhancement (NICE) rehabilitation, a novel neuromuscular control signal-guided strategy that visually guides stroke patients to individually activate motor modules through human-machine interaction. Ultimately, the development will lead to better clinical motor recovery, better quality of life, and lowered healthcare costs associated with the impairment.

Eligibility criteria

Qualifiers

Hemiparetic chronic stroke survivors more than 6 months after stroke onset

Adults aged 21-80 years, including both female and male participants

Individuals with a single unilateral ischemic or hemorrhagic stroke

Individuals with Upper Extremity Fugl-Meyer Assessment score between 10 and 59 out of 66

Disqualifiers

Individuals younger than 21 years of age or older than 80 years of age

Individuals with an orthopedic disorder involving the upper limbs

Individuals unable to produce voluntary upper-extremity muscle EMG activity;

Individuals with cognitive impairment sufficient to interfere with informed consent or successful completion of the protocol, assessed using the Montreal Cognitive Assessment or other IRB-approved screening procedures.

Trial design

Treatments tested in this trial

  • Neuromuscular coordination enhancement (NICE) intervention
  • EMG Amplitude Biofeedback Exercise

Treatment groups

48 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University of Houston

Lead sponsor

TIRR Memorial Hermann

Collaborator

The University of Texas Health Science Center, Houston

Collaborator