Pharmacokinetics of Oral Calcium Carbonate in Parturients
Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexFemale
Age18-45
SponsorStanford University
About this trial
This study investigates the time course of change in calcium in the blood after a pregnant subject takes an oral dose of calcium carbonate (commonly marketed as "Tums"). This information is important for trials investigating whether calcium can reduce postpartum hemorrhage, bleeding after delivery.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Pregnant female subjects at the study institution, admitted for labor (spontaneous, augmented, or induced)
Disqualifiers
severe range blood pressure (BP >160/>110) within the 48 hours prior to delivery
patient age <18 years or >45 years
renal dysfunction with a documented serum Cr > 1.0 mg/dL
known history of congenital or acquired cardiac disease or history of arrhythmia
Trial design
Design model
Single group
Treatments tested in this trial
Oral calcium carbonate
DrugAll participants receive a single, open-label dose of oral calcium carbonate 3000mg
Treatment groups
60 Participants
are divided into 1 treatment groupGroup A: Oral calcium carbonateExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Ionized calcium concentration
Ionized calcium (mmol/L) is measured at baseline and over 5 additional convenience timepoints over the 4 hours after ingestion of calcium carbonate 3000mg.
Time frame
4 hoursSponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: