Positron Emission Tomography (PET) Imaging of Cholesterol Trafficking: Clinical Evaluation of [18F]FNP-59 in Normal Human Subjects (Groups 2, 3 & 4)

Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorBenjamin Viglianti

About this trial

This study will evaluate the feasibility of using a sub-therapeutic dose of a fluorine-18 analogue of NP-59 (\[18F\]FNP-59) to image the adrenal gland. Some participants are healthy normal subjects but have undergone interventions to manipulate hormones while other participants have known adrenal pathology.

Eligibility criteria

Qualifiers

Participants without any known adrenal pathology as normal controls for undergoing endocrine manipulation

Disqualifiers

Pregnancy

Unable to do imaging

Body weight greater than 400 lbs (181 Kg)

Prisoners are not eligible

Trial design

Treatments tested in this trial

  • Dexamethasone (Group 2)
  • Cosyntropin (Group 3)
  • PET/CT Scan with FNP-59

Treatment groups

24 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Benjamin Viglianti

Lead sponsor

University of Michigan

Sponsor institution