Quadriceps Motor Unit Adaptation to Simulated Knee Injury
Trial statusRecruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18-30
SponsorUniversity of Central Florida
About this trial
This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscular testing during a single 2-hour lab session. This research seeks to improve understanding of muscle inhibition and inform interventions after real-world knee trauma.
Eligibility criteria
Qualifiers
Age 18-30 years
Physically active (Tegner ≥ 5)
No prior lower-limb surgery or major injury
Disqualifiers
Lower limb surgery or significant injury in past 2 years
Cardiopulmonary, neurological, or psychiatric disorders
Needle/electrical stimulation anxiety
Medications affecting neuromuscular or psychological function
Trial design
Treatments tested in this trial
- Joint Effusion via 60 mL Sterile Saline
- Intra-articular Lidocaine
- Sham injection
Treatment groups
45 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov