The overall objectives of the proposed research are to:
1. Evaluate the diagnostic validity of a novel mechano-acoustic signatures of task-characteristic activity during symptomatic and asymptomatic breathing in Exercise-Induced Laryngeal Obstruction (EILO) patients with the use of a novel miniature, soft wearable skin-mounted device, 2. Identify the mechanism/s of paradoxical respiratory control in EILO by quantifying the relationship between pulmonary mechanics, partial pressure of carbon dioxide (PCO2) maintenance, and vocal fold aperture prior to and during symptomatic and asymptomatic exercise ventilation, and 3. Identify unique biophysiological factors contributing to EILO among exercisers with and without EILO. Findings will be highly novel and clinically significant for early identification and management of EILO.
For the study there are three separate visits:
1. Free running with the device on the neck 2. Exercise treadmill study 3. Undergoing MRI (Magnetic Resonance Imaging) of the vocal tract.
Physically active >2.5 hours per week
Patients with EILO, as diagnosed by routine clinical examination by physician and/or speech language pathologist
Age range of 18-26 years
Greater difficulty breathing inside compared to out and difficulty breathing which is exacerbated at peak exercise and stops 1-5 minutes after exercise
Individuals older than 26 years and younger than 18 years of age.
Women who are pregnant or could possibly be pregnant.
BMI > 25 kg/m2
A 'yes' answer to any of the 14 questions on the PAR-Q pre-participation questionnaire
Indiana University
Lead sponsor
Purdue University
Collaborator
National Jewish Health
Collaborator
National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborator