Restructuring the Alpha-Gamma Code in Aging Vision
Trial statusNot yet recruiting
Trial phaseEarly Phase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorBoston University Charles River Campus
About this trial
Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and personalized complex-waveform HD-tACS to (1) quantify aging effects on phase-amplitude coupling, (2) drive PAC into a preferred "gamma-at-alpha-troughs" state, and (3) bidirectionally change perception by aligning gamma to alpha troughs vs peaks. Two five-day, double-blind, sham-controlled studies (n=120 each) target contrast sensitivity (V1) and 3D shape-from-motion (MT), aiming for mechanistic insight and remediation in older adults with implications for ADRD.
Eligibility criteria
Qualifiers
18+ years of age or older
normal or corrected-to-normal visual acuity, color vision, and stereo vision
Disqualifiers
not pregnant,
no metal implants in head,
no implanted electronic devices,
no history of neurological problems or head injury,
Trial design
Treatments tested in this trial
- High definition transcranial electrical current stimulation
Treatment groups
240 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov